EPILEPSY patient and dental treatment protocol
EPILEPSY patient
and dental treatment protocol
GENERALIZED: GRAND MAL
(TONIC-CLONIC)
EPILEPSY
Grand-mal epilepsy
usually begins in childhood, or sometimes at about puberty. There is a warning
(aura), followed by loss of consciousness, tonic and the clonic convulsions
and, finally, a variably prolonged recovery.
The aura may consist of
a mood change, irritability, brief hallucination or headache. The attack then
begins suddenly with total body tonic spasm and loss of consciousness. The
sufferer falls to the ground and is in danger of injury. Initially the face
becomes pale and the pupils dilate, the head and spine are thrown into
extension (opisthotonos), and glottic and respiratory muscle spasm may cause an
initial brief cry and cyanosis. There may also be incontinence and biting of
the tongue or lips. The tonic phase passes, after less than a minute, into the
clonic phase, when there are repetitive jerking movements of trunk, limbs,
tongue and lips. Salivation is profuse with bruxism, sometimes tongue-biting
and, occasionally, vomiting. There may be urinary or faecal incontinence, and
autonomic phenomena such as tachycardia, hypertension and flushing. Clonus is
followed by a state of flaccid semi-coma for a further 10-15 min. Confusion and
headaches are common afterwards and the patient may sleep for up to 12 h or
more before full recovery. The attack may occasionally be followed by a
transient residual paralysis (Todd palsy) or by automatic or aggressive
behaviour. This full sequence is not always completed.
Complications of major convulsions can be trauma , respiratory embarrassment or brain damage, or progress to status epilepticus, but most seizures end without mishap. A major fit is so dramatic that it seems to be of longer duration than is in fact the case but, if it lasts more than 5 min (by the clock) or starts again after apparently ceasing, the patient must be regarded as being in status epilepticus, which is particularly dangerous - the mortality rate can be up to 20%. Brain damage may result from cerebral hypoxia, when tonic and clonic phases alternate repeatedly without consciousness being regained and there can also be inhalation of vomit and saliva. Status epilepticus is a medical emergency by causing severe hypoxia, and is potentially fatal.
PARTIAL SEIZURES "
Petit-mal seizures come
most often during childhood and are characterized by minimal or no movements
(except for eye- blinking) and an apparently blank stare; brief sudden loss of
awareness or of conscious activity that may only last seconds; recur many times
and involve learning difficulties (child often thought to be day dreaming). Most
patients who have petit mal also have grand-mal attacks.
Simple partial (focal)
seizures can be motor, sensory or behavioural, typically remain confined to one
area, and include muscle contractions of a specific body part [focal motor
epilepsy, which may take the form of clonic movements of a limb or group of
muscles, usually in the face, arm or leg though the clonus may spread (march)
to adjacent muscles on the same side of the body (Jacksonian epilepsy)];
abnormal sensations; sometimes nausea, sweating, skin flushing, and dilated
pupils; sometimes other focal (localized) symptoms.
Partial complex
seizures, or temporal lobe epilepsy (psychomotor epilepsy), are characterized
by automatism (automatic performance of complex behaviours) such as
lip-smacking and chewing movements, or facial grimacing; recalled or
inappropriate emotions; changes in personality or alertness; sometimes
disorientation, confusion and amnesia, or loss of consciousness; sometimes olfactory
(smell) or gustatory (taste) hallucinations or impairments.
Table 13.31
Anticonvulsant treatment of epilepsy |
||
Type of epilepsy |
Drugs |
Adverse effects |
Tonic-clonic seizure |
Carbamazepine
Phenytoin Sodium valproate Gabapentin |
Skin rashes Blood dyscrasias
Liver impairment |
Absence seizure |
Sodium valproate
Ethosuximide |
Sleep disturbance |
Partial seizures |
Carbamazepine Sodium
valproate |
As above |
DENTAL ASPECTS
Dental treatment should
be carried out in a good phase of epilepsy, when attacks are infrequent.
Various factors can precipitate attacks (Box 13.11).
Box 13.11 Factors
sometimes precipitating fits in susceptible subjects
·
Withdrawal of
anticonvulsant medication
·
Epileptogenic drugs (Box
13. 12)
·
Fatigue, starvation or
stress
·
Infection
·
Menstruation
·
Flickering lights
(television; strobe lights)
Those who have
infrequent seizures or who depend on others (such as those with a learning
impairment) may fail to take regular medication and thus be poorly controlled.
When carrying out dental treatment in a known epileptic, a strong mouth prop
should be kept in position and the oral cavity kept as free as possible of
debris. As much apparatus as possible should be kept away from the area around
the patient. Drugs can be epileptogenic or interfere with anticonvulsants, or
can themselves be changed by anticonvulsant therapy and may, therefore, be
contraindicated (Tables 13.32 and 13.33 and Box 13.12).
In the past,
particularly, gingival swelling due to phenytoin required treatment by gingival
surgery. Carbamazepine or gab- apentin obviate this problem.
Table 13.32 Drugs used
in dentistry that can increase anticonvulsant activity, leading to overdose |
|
Aspirin |
Can increase the
bleeding tendency induced by valproate |
Azole antifungals |
Can interfere with phenytoin |
|
Can increase the
bleeding tendency induced by valproate Can interfere with
carbamazepine |
Metronidazole |
Can interfere with
phenytoin Can increase the
bleeding tendency induced by valproate |
Propoxyphene |
Can interfere with
carbamazepine |
Table 13.33 Drugs used
in dentistry whose activity can be altered by anticonvulsants |
|
Acetaminophen |
Hepatotoxicity may be
increased by anticonvulsants |
Doxycycline |
Metabolism may be
increased by carbamazepine |
Box 13.12 Drugs
contraindicated in epilepsy
·
Alcohol
·
Chlorpromazine
·
Enflurane
·
Flumazenil
·
Fluoxetine
·
Ketamine
·
Lidocaine (large doses)
·
Metronidazole
·
Quinolones
·
Tramadol
·
Tricyclic
antidepressants
Aspirin, azoles and metronidazole can interfere with phenytoin. Propoxyphene and erythromycin can
interfere with carbamazepine.
Large doses of lidocaine
given intravenously for severe arrhythmias may occasionally cause convulsions.
An overenthusiastic casualty officer may therefore blame a dental LA for
causing a fit. There is no evidence that this can happen, especially as
intravenous lidocaine has also been advocated for the control of status
epilepticus.
Conscious sedation in
epilepsy should be safe. Stress reduction should reduce the chance of a fit.
Benzodiazepines are anti-epileptogenic, but occasionally fits have been
recorded in epileptics undergoing intravenous sedation with midazolam.
Flumazenil, however, can be epileptogenic. Nitrous oxide can increase the CNS
depression in patients on anticonvulsants. It is probably best to avoid
electronic dental analgesia.
Acrylic is probably
better used for prostheses than porcelain, as it is more resilient.
Convulsions may have
craniofacial sequelae, especially lacerations, haematomas and fractures. Trauma
frequently results from a grand-mal attack when the patient falls unconscious
or
from the muscle spasm,
and a range of injuries can result [e.g. fractures of the vertebrae or limbs,
dislocations, periorbital subcutaneous haematomas in the absence of facial
fractures, injuries to the face from falling (lacerations, haematomas, fractures
of the facial skeleton), fractures, devitalization, subluxation or loss of
teeth (a chest radiograph may be required), TMJ subluxation, or lacerations or
scarring of the tongue, lips or buccal mucosa].
FEBRILE CONVULSIONS
Febrile convulsions are
more common than epilepsy, usually affect children and result from a rise in
body temperature commonly caused by infection. Children who develop high fevers
(above 38°C) should therefore be put in a cool environment, and bathed with
tepid water and given acetaminophen elixir (not aspirin). Children under 18 months should be admitted to
hospital since the fit may be due to meningitis. Severe febrile convulsions can
cause brain damage and about 3% of children with febrile convulsions go on in
later life to develop epilepsy; most do not.
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